2025 Medical Review Officer Online Course with Live Discussion (Includes Digital Syllabus)-Tab 12

Video Transcription

Video Summary

The video discusses oral fluid drug testing, focusing on collection procedures, devices, guidelines, and laboratory analysis per Department of Health and Human Services (HHS) and Department of Transportation (DOT) standards. Oral fluid testing offers observed collection, can be done onsite without special facilities, and serves as an alternative when urine isn't available (e.g., shy bladder). Collectors follow strict protocols, including a 10-minute observation period and use FDA-cleared devices, some capable of split specimen collection for DOT testing. Specimens are sent to certified labs for analysis, employing sensitive immunoassays and mass spectrometry (LC-MS-MS). Oral fluid testing detects parent drugs, not metabolites, with lower detection cutoffs than urine, enhancing sensitivity. Marijuana testing targets the parent compound due to oral cavity retention rather than metabolites. Oral fluid drug testing shows higher positivity rates for many drugs compared to urine, attributed to reduced dilution and observed collection minimizing tampering. No standardized specimen validity test exists yet, but observation aims to ensure sample integrity.

Keywords

oral fluid drug testing

collection procedures

HHS and DOT guidelines

FDA-cleared devices

laboratory analysis

drug detection sensitivity