A Study on Non-Vibration-Exposed Organs Correlated Indices as Diagnostic Biomarkers of Hand-Arm vibration Syndrome (November 2024)-A study on non-vibration-exposed organs correlated indices as diagnostic biomarkers of hand-arm vibration syndrome

A study on non-vibration-exposed organs correlated indices as diagnostic biomarkers of hand-arm vibration syndrome

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The study explores the feasibility of using biomarkers from non-vibration-exposed organs to diagnose Hand-Arm Vibration Syndrome (HAVS), particularly its most emblematic symptom, Vibration-Induced White Finger (VWF). Conducted on workers in a Chinese factory, individuals were categorized into control, non-VWF, and VWF groups based on their exposure to hand-transmitted vibration and presence of VWF.<br /><br />Blood tests examining multiple biomarkers, including insulin (INS) and aspartate aminotransferase (AST), were conducted, showing high diagnostic potential for VWF. Analysis of Receiver Operating Characteristic (ROC) curves for these biomarkers indicated a high diagnostic sensitivity, with the area under the curve being 0.909 for insulin and 0.923 for AST. These results suggest that measures from non-vibration-exposed organs, particularly levels of INS and AST, might serve as additional diagnostic indicators of HAVS, enhancing diagnostic accuracy beyond traditional methods which rely heavily on nerve electromyography and tests inducing cold exposure symptoms. <br /><br />The study also highlighted a lack of significant literature connecting vibration exposure to systematic organ damage, asserting that HAVS not only affects areas subjected to direct vibration but also the digestive and endocrine systems. Additionally, conferences with control and non-VWF groups showed elevated levels of biomarkers like lipase, alanine aminotransferase (ALT), glucagon (GC), and others in those experiencing VWF, suggesting early pancreatic and liver differences that could aid diagnosis in warmer regions without easily demonstrable VWF symptoms.<br /><br />This research presents an initial examination but calls for further verification through diverse, systematic models to substantiate these conclusions and validate INS and AST as reliable biomarkers for early HAVS detection.

Keywords

Hand-Arm Vibration Syndrome

Vibration-Induced White Finger

biomarkers

insulin

aspartate aminotransferase

diagnostic potential

Receiver Operating Characteristic

systematic organ damage

pancreatic and liver differences

early detection