JOEM: An Increase in Plasma Adipsin Levels (March 2023)-JOEM: An Increase in Plasma Adipsin Levels (March 2023)

JOEM: An Increase in Plasma Adipsin Levels (March 2023)

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A study conducted on foundry workers aimed to assess the association between plasma adipsin levels and pulmonary function. The study examined 65 dust-exposed foundry workers and 40 nonexposed controls, analyzing their lung function and plasma adipokine levels at baseline and after approximately 7 years of follow-up. The results showed that a higher increase in plasma adipsin was associated with the development of airway obstruction in exposed subjects during the follow-up period. The increase in adipsin levels was also positively associated with cumulative dust exposure. The study suggests that plasma adipsin is involved in the pathogenesis of subclinical airway inflammation and the development of chronic obstruction, and is induced by occupational dust exposure. The study also analyzed the effects of cumulative dust exposure on the serum levels of adipsin during the follow-up, finding a positive association between the two. Overall, the findings indicate that occupational dust exposure in foundry workers can lead to increased adipsin levels and subsequent airway obstruction.

Keywords

plasma adipsin levels

pulmonary function

foundry workers

dust-exposed

nonexposed controls

lung function

adipokine levels

airway obstruction

cumulative dust exposure

subclinical airway inflammation