JOEM: Effects of polycyclic aromatic hydrocarbon exposure (February 2024)-Effects of polycyclic aromatic hydrocarbon exposure (February 2024)

Effects of polycyclic aromatic hydrocarbon exposure (February 2024)

Pdf Summary

A recent study aimed to investigate the effects of polycyclic aromatic hydrocarbon (PAH) exposure and telomere length on blood lipids in coal miners. The study collected data from 637 coal miners and analyzed the effects of PAH metabolites and telomere length on blood lipids using logistic regression, the Bayesian kernel machine regression model, and weighted quantile sum regression. The results showed that high exposure to 9-hydroxyphenanthrene, a PAH metabolite, and telomere shortening were associated with dyslipidemia. Weighted quantile sum results indicated that 9-hydroxyphenanthrene accounted for the largest proportion of dyslipidemia. The interaction results suggested that high 9-hydroxyphenanthrene exposure and short telomeres were risk factors for dyslipidemia in coal miners. This study provides evidence that 9-hydroxyphenanthrene and shorter telomeres are risk factors for dyslipidemia, and their interaction increases the risk of dyslipidemia.<br /> <br />Cardiovascular diseases are a leading cause of death globally and have a significant impact on the quality of life. Dyslipidemia, an abnormal lipid profile, is a major risk factor for cardiovascular diseases. Various factors, including genetic factors, environmental pollutants, diet, and lifestyle, contribute to the development of dyslipidemia. Coal miners, who are often exposed to polycyclic aromatic hydrocarbons (PAHs) due to their occupation, are at a higher risk of developing dyslipidemia. PAHs can be absorbed by coal miners through breathing, diet, and skin contact. Previous studies have shown that PAH exposure is positively correlated with the risk of cardiovascular diseases and is associated with hypertension and dyslipidemia. Telomeres, the protective caps at the ends of chromosomes, play a role in cell division and are associated with various health conditions, including obesity, diabetes, metabolic syndrome, and cardiovascular disease. However, there is limited research on the effects of PAH exposure and telomere length on dyslipidemia in coal miners and whether there is an interaction between these factors. This study aimed to fill this gap by investigating the effects of PAH exposure and telomere length on blood lipids in coal miners. The findings suggest that high exposure to 9-hydroxyphenanthrene and shorter telomeres are risk factors for dyslipidemia, and their interaction increases the risk of dyslipidemia. These findings have implications for the early prevention and management of dyslipidemia in coal miners.

Keywords

polycyclic aromatic hydrocarbon exposure

telomere length

blood lipids

coal miners

PAH metabolites

logistic regression

Bayesian kernel machine regression model

weighted quantile sum regression

dyslipidemia

9-hydroxyphenanthrene