JOEM: Exposure to perfluoroalkyl substances (February 2024)-Exposure to perfluoroalkyl substances (February 2024)

Exposure to perfluoroalkyl substances (February 2024)

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A recent study investigated the relationship between exposure to perfluoroalkyl substances (PFAS) and hyperlipidemia, a condition characterized by elevated levels of lipids in the blood, using data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. The study included 1,600 subjects, and nine different PFAS were measured. The analysis showed that elevated levels of perfluoromethylheptane sulfonic acid isomers (Sm-PFOS) were associated with a higher risk of hyperlipidemia. Compared to the lowest quartile of Sm-PFOS, the third and highest quartiles of PFOS showed a 57% and 41% increase in the risk of hyperlipidemia, respectively. This association remained significant in individuals under the age of 60, with the fourth quartile of Sm-PFOS showing an odds ratio of 1.81 for hyperlipidemia. The study concluded that serum Sm-PFOS was independently associated with a higher risk of hyperlipidemia and suggested further research to understand the causal relationship between PFAS exposure and the condition. PFAS are synthetic chemicals used in various products, including food packaging and nonstick cookware, and have been linked to adverse health effects such as dysregulated metabolism and endocrine disruption. Strict prevention and management of hyperlipidemia, as well as monitoring and stricter regulation of PFAS exposure, were recommended based on the findings of the study.

Keywords

perfluoroalkyl substances

PFAS

hyperlipidemia

lipids

blood

Sm-PFOS

quartiles

odds ratio

exposure

health effects