JOEM: Glucose Metabolism in Midlife (February 2023)-JOEM: Glucose Metabolism in Midlife (February 2023)

JOEM: Glucose Metabolism in Midlife (February 2023)

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A study conducted on a Northern Finland Birth Cohort 1966 aimed to evaluate how glucose metabolism in mid-life is related to the preceding 30-year-long employment trajectories. The study compared glucose metabolism at age 46 to employment trajectories in the cohort. The results showed that compared to individuals in high-educated trajectories, the odds ratios for type 2 diabetes (T2D) were higher in traditional and floundering trajectories in men, and in traditional, floundering, and self-employed trajectories in women. The highest risks for T2D in midlife were associated with traditional and floundering trajectories in both men and women, and with the self-employment trajectory in women. The study concluded that accumulating unemployment and self-employment may increase the risk of T2D in midlife, emphasizing the need for targeted interventions for diabetes prevention in these populations. However, the study had limitations including its retrospective design, potential selection bias due to attrition in the cohort, and the low prevalence of T2D at age  46. Further research is needed to confirm these findings and investigate the underlying mechanisms between employment trajectories and glucose metabolism.

Keywords

Northern Finland Birth Cohort 1966

glucose metabolism

employment trajectories

type 2 diabetes

T2D

traditional trajectory

floundering trajectory

self-employment trajectory

unemployment

diabetes prevention