JOEM: Occupational exposures and lung cancer risk – an analysis... (April 2022)-JOEM: Occupational exposures and lung cancer risk

JOEM: Occupational exposures and lung cancer risk – an analysis... (April 2022)

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A case-cohort study conducted within the CARTaGENE prospective cohort study aimed to determine the associations between occupational exposures and lung cancer risk. The study used the Canadian Job Exposure Matrix to estimate the participants' probability of exposure to 27 occupational agents in their longest-held jobs. Multivariable logistic regression was used to determine the associations between each agent and lung cancer risk. The results showed that exposure to certain occupational agents was associated with an increased risk of lung cancer, including ashes, calcium sulfate, formaldehyde, cooking fumes, alkanes, aliphatic aldehydes, and cleaning agents. On the other hand, exposure to carbon monoxide and polycyclic aromatic hydrocarbons (PAHs) from petroleum was associated with a lower risk of lung cancer. The study concluded that several occupational agents, for which there is limited knowledge, contribute to lung cancer risk. The findings highlight the importance of considering occupational exposures as a potential factor in the development of lung cancer. Further research is needed to explore the dose-response relationship and the mechanisms underlying these associations.

Keywords

case-cohort study

occupational exposures

lung cancer risk

Job Exposure Matrix

formaldehyde

cooking fumes

alkanes

cleaning agents

carbon monoxide

PAHs