JOEM: Perfluoroalkyl substances and abdominal aortic calcification (April 2022)-JOEM: Perfluoroalkyl substances and abdominal aortic calcification (April 2022)

JOEM: Perfluoroalkyl substances and abdominal aortic calcification (April 2022)

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A study evaluated the association between serum perfluoroalkylated substances (PFAS) and abdominal aortic calcification (AAC). The study used data from the National Health and Nutrition Examination Survey (NHANES) and focused on participants aged 40 years and older. The results showed that after adjusting for confounding factors, such as age, gender, race/ethnicity, smoking status, and socioeconomic status, none of the PFAS compounds (including perfluorooctanoic acid, perfluorooctane sulfonate, perfluorohexane sulfonic acid, and perfluorononanoic acid) were significantly associated with AAC for either men or women. However, a positive association between PFAS compounds and AAC was observed in women, although this difference was not statistically significant in either case. The findings suggest that there is no general support for a relationship between PFAS exposure and AAC, but gender-specific considerations may be necessary in larger datasets. It is worth noting that this study has some limitations, as it is based on cross-sectional data and focused on a specific age group. Further research is needed to better understand the potential effects of PFAS exposure on cardiovascular health.

Keywords

PFAS

abdominal aortic calcification

NHANES

gender

association

exposure

cardiovascular health

cross-sectional data

age group

research