Psychological General Well-being, Cognitive Failure, and Inflammation Biomarkers Among Workers 4 Months After a Mild/AsymptomaticSARS-CoV-2 Infection (Otcober 2024)-Psychological General Well-being, Cognitive Failure, and Inflammation Biomarkers Among Workers 4 Months After a Mild/AsymptomaticSARS-CoV-2 Infection

Psychological General Well-being, Cognitive Failure, and Inflammation Biomarkers Among Workers 4 Months After a Mild/AsymptomaticSARS-CoV-2 Infection

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The study conducted by Angela Stufano and colleagues examines the relationship between cognitive complaints, systemic inflammatory biomarkers, and psychological general well-being (PGWB) among workers four months after mild or asymptomatic SARS-CoV-2 infection. This cross-sectional study involved university employees and metal workers, assessing cognitive impairment, PGWB, inflammatory biomarkers including platelet-lymphocyte, neutrophil-lymphocyte, and lymphocyte-monocyte ratios, and presence of long COVID symptoms.<br /><br />Key findings highlight that individuals experiencing long COVID exhibited significantly elevated levels of inflammatory biomarkers, which correlate with systemic inflammation. Psychological well-being was adversely affected in individuals with long COVID, experiencing increased cognitive failures and depressive symptoms, although this did not vary significantly across different types of work activities. The levels of general stress or distress and quality of life in these individuals were notably reduced compared to their state prior to the pandemic.<br /><br />The significance of identifying and treating long COVID symptoms early in occupational settings is emphasized due to their potential drastic effects on psychological well-being and functionality at work. Moreover, the study supports using inexpensive and easily measurable inflammatory biomarkers, which could possibly serve as diagnostic tools for detecting systemic inflammation linked to long COVID sequelae.<br /><br />The study recognizes limitations such as sample size, single-center focus, and lack of a non-infected control group, advising that future research should include more diverse occupational settings and consider objective cognitive testing alongside self-report instruments. It underscores the importance of monitoring PGWB as part of occupational health strategies, advocating for a deeper understanding of systemic inflammation's role in long COVID and its impact on psychological general well-being.

Keywords

cognitive complaints

systemic inflammatory biomarkers

psychological general well-being

long COVID

SARS-CoV-2 infection

inflammatory biomarkers

occupational health

cognitive impairment

depressive symptoms

systemic inflammation